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80% of the clinical data of new drugs are involved in fraud, which link has gone wrong？

　　According to official website data of the State Food and Drug Administration, as of January 21st, 2016, due to the untrue and incomplete clinical trial data, the number of drug registration applications rejected by the State Food and Drug Administration and withdrawn by pharmaceutical companies for self-examination was as high as 1,184, accounting for 73% of the total number required for self-examination. If 165 clinical exemptions are deducted, the proportion will reach 81%.

　　The staff of the food and drug department said that during the verification, it was found that the clinical trial data of many drugs were incomplete, the analysis data had no differential trajectory, and some data could not be traced back. Other companies deliberately concealed or omitted the adverse reaction records, and revised the test data that failed to meet expectations.

　　At the beginning of September, a report that "80% of the clinical data of new drugs are involved in fraud, and the regulatory links are falling behind" caused a shock. The direct consequence of clinical data fraud is poor efficacy. To some extent, clinical data fraud affects everyone.

　　According to the news, over 80% of the clinical data of new drugs have been found to be fake since china food and drug administration started the self-inspection and verification of drug clinical trial data one year ago, and the regulatory links behind them have fallen behind, and the violations of relevant subjects such as pharmaceutical companies, intermediaries and doctors are prominent.

　　The data of drug clinical trials are of great significance in drug research and development innovation, and standardized clinical trials with reliable data are the key link to ensure drug quality. As the last link of new drug research and development, whether the drugs developed with tens of millions or even hundreds of millions of yuan have curative effect and safety depends mainly on the experimental data. The falsification of drug clinical trial data will not only bring huge security risks to patients’ medication, but also affect the innovation and upgrading of China’s pharmaceutical industry.

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　　Fraud in clinical trials is no longer news.

　　The results of clinical trials are not only the only standard to test the safety and effectiveness of drugs, but also the key basis for drug registration and listing. Pei yu, director of the Department of Pharmacy, School of Pharmacy, Jinan University, said that clinical trials with strict specifications and reliable data are a key safety barrier before the drug goes on the market, and also the core basis for drug supervision departments to support the drug listing. However, the survey found that it is no longer news that Chinese drugs were faked in the clinical trial stage before listing.

　　Data fraud began in preclinical research. "Before a drug goes on the market, human clinical trials must be done. However, from the moment the subjects were selected to join the group, fraud occurred all the time. " The person in charge of a pharmaceutical company, who asked not to be named, said that clinical trials often adopt the method of "competitive enrollment". The number of participants in the group will directly determine the doctor’s signature ranking and the amount of scientific research funds in the future. If a project needs 100 patients who meet the test requirements, but it does not get enough people before the planned date, the test may start with only 80 or even 60 people. In the face of lack, data can only be fabricated from scratch.

　　Not only that, the actual operation record is not true and it is also a common means of fraud. According to a survey conducted by China Journal of Clinical Pharmacology in 2013 on domestic experimental institutions, the proportion of non-standard experimental records is as high as 85.7%, which is the most problematic link in clinical trials, and only 1/7 institutions in China have not found any problems.

　　Fraud may appear in any link of clinical trials.

　　It is a consensus in the medical field that generic drugs should be equal to the original drugs in dosage form, specification, quality, efficacy and indications. Some pharmaceutical companies launch generic drugs in order to maximize profits, but the necessary link of clinical trials is often "ignored". The boss of a large biopharmaceutical company revealed that 90% of domestic generic drugs could not meet the original research standards. In order to pass the evaluation, it is very common to conceal data and selectively use data, and pharmaceutical companies even modify data in conjunction with doctors.

　　"The clinical data of drugs are untrue and irregular, and the reasons may not all be caused by enterprises." The general manager of a pharmaceutical company in Zhejiang said that there are many reasons and motivations, which may appear in any link of the whole chain of clinical trials. On the one hand, China’s current laws and regulations on drug clinical trial supervision are still not perfect; On the other hand, the number of drug clinical trial institutions is too small, which is seriously mismatched with the number of projects that need to carry out clinical trials every year, which leads to the overwhelming burden of clinical trial institutions and affects the quality and standardization of clinical trials.

　　question

　　Data fraud supervision is still "soft"

　　The extremely important data in clinical trials of new drugs are often ignored nowadays. In foreign countries, data statistics need to spend hundreds of thousands or even millions of RMB, while data statistics in China hospitals only need to spend tens of thousands of RMB.

　　China implements the qualification certification system for clinical trial institutions, that is, only clinical institutions that have passed the examination and approval of drug supervision departments can participate in clinical trials. The actual situation is often that it is very difficult for new drug trials to enter phase I clinical trials, but once they enter, they will be smooth all the way.

　　Traditionally, pharmaceutical companies often send inspectors (CRA) to supervise clinical trial institutions. After the clinical trial, CRA will collect the approved data and hand it over to the data processing institution for analysis and collation, and finally form the data and report submitted to the Drug Evaluation Center of the Food and Drug Administration for review. However, due to the lack of third-party supervision and checks and balances, hospitals as clinical trial institutions have frequent problems. In order to achieve the purpose of approval, some pharmaceutical companies will also modify the data in conjunction with statistical units. Although the General Administration clearly stipulates that if the clinical research data is fraudulent, the applicant’s new application for drug registration will not be accepted within 3 years, and the clinical trial data of the person directly responsible for participating in the research or organizing the research will not be accepted within 10 years. However, for a series of data fraud problems, supervision is still "soft".

　　Dr Liao Guojuan, CEO of Suzhou Jinweizhi Biotechnology Co., Ltd. said that in the United States, once data fraud occurs, pharmaceutical companies and R&D personnel will be blacklisted and will not be allowed to enter related fields for life.

　　counter-measure

　　New drug research and development must take the right path

　　Since April 2015, a number of new policies for drug trial reform have been introduced almost every month. On November 11th, last year, china food and drug administration also published the Announcement of china food and drug administration on Several Policies of Drug Registration Review and Approval in its official website, and put forward ten heavy new regulations, such as improving the approval standard of generic drugs and optimizing the review and approval of clinical trial applications. This may be a blessing for the creation of real new drugs with clinical value. However, after a lapse of one year, the news that 80% of the clinical data of new drugs are suspected of being falsified still broke out, which has to make people ponder: which link has gone wrong?

　　For the current situation of new drug research and development, the general manager of a pharmaceutical company in Nanjing feels very helpless: formal enterprises take the right path, only to find that enterprises that resort to deceit and cut corners are faster than their own approval.

　　The president of a biotechnology company in Shenzhen also said that many innovative companies that focus on drug research and development have made an innovative drug for ten years, and the data have been carefully made, but they have suffered losses when competing with companies that falsify data. "Strict review of clinical research data should not only be implemented early, but also be promoted. Although the progress of regular products may be affected in the short term, after the normalization, on the whole, it is conducive to the healthy development of innovative enterprises. "

　　Encourage real innovation with the strictest system

　　Some people in the medical field believe that there are two negative arguments to be vigilant at present: first, the introduction of policies should conform to China’s national conditions, and the requirements for innovation at this stage should not be too advanced; Second, the policy cannot be uniform, and some clinical data are just not standardized, not fraudulent, and should be allowed to exist.

　　In this regard, experts suggest that to ensure the authenticity of drug clinical data, we can refer to the advanced and mature practices in Europe and America, and have zero tolerance for clinical data fraud and other chaos, so as to effectively ensure the safety of patients’ medication; At the same time, more doctors should be allowed to engage in drug clinical trials and control the quality of clinical trials; Establish a third-party supervision system and strengthen supervision. In addition, electronic information technology can also be used to establish a database of drug clinical trials, requiring clinical institutions to report clinical trial data in real time and make it public, so as to realize universal supervision.

　　Authorities in the industry said that at present, it is a critical period to control "bad money drives out good money" in the field of drugs, and real innovation must be encouraged with the strictest system. Therefore, it is called for the revision of the "Quality Management Standards for Drug Clinical Trials" and other laws and regulations as soon as possible to further improve the system supervision; At the same time, the internal supervision system of pharmaceutical companies should be established to truly form core competitiveness through innovation. (Reporter Li Ying)

Super Mario Bros. Movie has exceeded $1.2 billion at the global box office.

1905 movie network news It is reported that the box office performance of the film continues to climb, and the global box office of the film has exceeded $1.2 billion, reaching $1.21 billion! Super Mario Bros. Movie not only became the first "Billion Club" movie in 2023, but also the highest-grossing movie in the world this year. At the same time, the film is also the total box office champion of the film history of game adaptation.


It is reported that "Hollywood Report" once conducted a survey on the adaptation of movies from games. The survey concluded that Nintendo’s Super Mario Bros. is the game adaptation film that Americans most want to see, so the film is generally optimistic at the North American box office. In the sixth week of its release in North America, Super Mario Bros. Movie reached US$ 13 million, a decrease of only 30.1% compared with the previous weekend. The cumulative total box office in North America was US$ 530 million, rising to the 24th place in the single box office of North American film history and the 5th place in the box office of animated films of film history. At the same time, the film also created the highest box office record for lighting and entertainment.


The film grossed $26.1 million overseas over the weekend, totaling $674.5 million (including 164 million yuan at the box office on the 41st day of its release in mainland China)! Overseas ticket warehouses include Mexico, Britain, Japan, France, Germany, Australia, Spain, Brazil, China and Italy. Among them, Japan, the hometown of Mario Brothers, ranked third in overseas ticket warehouses with a box office of 59.8 million US dollars, Mexico ranked first with a box office score of 82.4 million US dollars, followed by the United Kingdom with 63.2 million US dollars.


Super Mario Bros. is the best-selling game series in history. After its first release in 1981, it became popular all over the world. The film and television circle has put it on the screen several times. This film was jointly created by Nintendo and Lighting Entertainment, with the voices of Seth Rogan, Jack Black and Jigan michael kay.


At present, no sequel has been exposed.


Maoming, Guangdong issued the first flood red warning this year.

　　CCTV News:According to "Maoming released" WeChat WeChat official account news, affected by Typhoon Sanba and weak cold air, from October 19th to 20th, there was a large-scale rainstorm to a heavy rainstorm in Maoming. Maoming Hydrological Branch decided to upgrade the level IV emergency response of flood control hydrological forecasting to level III emergency response of flood control hydrological forecasting from 2: 00 on October 20th, further strengthen the duty on duty, and continuously do a good job in water and rain monitoring, forecasting and early warning.

　　Affected by continuous rainfall, the water level of rivers in Maoming area generally rose. According to the current water and rain situation and the future rainfall trend, Maoming Hydrological Branch has successively issued flood warnings for many rivers. Among them, Maoming Station of Xiaodongjiang is expected to reach the flood level of 12.5 meters, with the warning level exceeding 3.5 meters. Changshanyuan Station, Chejiaoshan Station and Baishacun Station along the river all exceed the warning level by more than 1 meter. The water level of Shatian Station of Shatian River in Gaozhou City has risen sharply, and it is expected that the warning level will exceed 3 meters, which may lead to dike overflow and dike break. Maoming Hydrological Branch issued the first red flood warning this year at 3: 00 on October 20th. In addition, Shatian River and Rudong River issued red flood warnings, Meihuajiang and Jianjiang issued orange flood warnings, Luojiang and Pingdingshui issued yellow flood warnings, and Caojiang, Xindong River, Huanghua River and Qianpai River issued blue flood warnings.

　　Maoming Hydrological Branch will closely monitor the water and rain conditions, provide accurate hydrological information forecast to relevant departments in time, provide scientific basis for flood control and disaster relief decision-making, and send information to remind relevant units along the river and the public to pay attention to dike safety and do a good job in defense, risk avoidance and disaster reduction.

Is eating dietary fiber just to lose weight？ You underestimate its power.

Article source: Vita Dog Nutritionist

China Clinical Nutrition Network has been authorized to reprint

Author: Peng Yigu (Master of Food Science, research direction: food nutrition and hygiene)

Please put on two more clothes before reading this article, because knowledge is a little cold. To tell the truth, I have already prepared my mind, and the reading volume may not be very high, but you don’t know, this is the basic knowledge of nutrition. After learning, you will know that keeping in good health is such a simple thing.

Just as building a house requires laying a foundation, dogs, as a popular science worker, must teach you these basic knowledge so that you can learn better and more steadily.

Therefore, please read this article patiently, and you will gain a different life. Starting today’s program, how can dietary fiber be used? Why does your impression of it only stop at losing weight? Is all this a distortion of human nature or a moral decay? Welcome to "Approaching Science": Dietary Fiber-the Guardian of Human Health.

Next you will see:

1. What exactly is dietary fiber?

2. How strong is dietary fiber?

3. Food sources of dietary fiber

4. Three misunderstandings of dietary fiber

Nutrition experts are always reminding: to eat more dietary fiber, what is it? The professional definition is: polysaccharide that exists in plants and cannot be digested and absorbed by human body. Speak human words …

First of all, as long as the food grows in the ground, it contains dietary fiber, not just vegetables, fruits and whole grains you think. Like mushrooms and nuts, they are also rich in dietary fiber (which we will talk about later).

Secondly, dietary fiber is a kind of carbohydrate, which can be divided into simple and complex schools. Dietary fiber is a disciple of polysaccharide under complex schools, and this disciple is very different.

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Why is it different? Because it can neither be digested nor absorbed by the human body, nor can it provide energy for the human body. See? Why do people think of losing weight when it comes to dietary fiber? I think the root cause lies here. So, dietary fiber seems to be useless, a waste? No, outstanding people are often different. Dietary fiber has made great contributions to our human body. Read on.

Before clarifying this question, let’s learn about the classification of dietary fiber.

1. The classification of dietary fiber

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Water solubility, as the name implies, means that this kind of fiber can be dissolved in water, just like cement, which will swell up after absorbing water and make the food ball sticky. For a simple example, when people soak oatmeal, have you noticed that it becomes sticky after a long time? This is due to the water-soluble fiber in oats.

Although water-insoluble dietary fibers are insoluble in water, they are mixed in the food ball, just like steel bars, which is beneficial to prop up the food ball and make it bigger, thus increasing satiety and stimulating intestinal peristalsis. They are inseparable friends, and most plant foods contain both dietary fibers.

2. The role of dietary fiber

It is precisely because dietary fiber can get rich when it meets water, oh no, it gets fat when it meets water, and it is firmly bonded with other substances, so the health effect is increasing.

First of all, of course, it is well-known to lose weight.

Controlling weight is beneficial to losing weight.

Reason: The combination of dietary fiber and food can increase the volume and consistency in the stomach and increase the feeling of fullness, thus making you eat less. Plus it can’t provide energy, which helps you reduce your energy intake.

Reduce serum cholesterol and prevent heart disease.

Reason: Here we want to talk about a substance called bile acid, which is a component of digestive juice and secreted by the liver, and can promote our body’s absorption of fat and cholesterol.

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However, dietary fiber can adsorb bile acids.

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With less bile acid, the absorption rate of fat and cholesterol will decrease, which is beneficial to the decline of blood lipid, which also reduces the risk of coronary heart disease.

Conducive to controlling blood sugar and maintaining balance.

Reason: First of all, dietary fiber will not increase blood sugar because it will not be digested and absorbed by the intestine and will not provide energy. In addition, dietary fiber mixed with chyme can also reduce the absorption of sugar in food by small intestine, thus slowly raising blood sugar.

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Because dietary fiber comes forward, the pancreas does not need to secrete so much insulin to metabolize sugar, which also reduces the working pressure of the pancreas, thus reducing the occurrence of diabetes.

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Conducive to the growth of intestinal probiotics

Reason: Water-soluble dietary fiber can be fermented by intestinal bacteria to synthesize short-chain fatty acids, which is a hotbed for probiotics. Short-chain fatty acids can also adjust the PH value of the intestine, which is more conducive to the growth of probiotics. When probiotics are strong, harmful bacteria in the intestines can’t make waves, and the intestines are healthier.

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Enhance intestinal function, which is beneficial to waste discharge.

Reason: As we said just now, dietary fiber expands when it meets water, and when it is combined with stool, it can make it bigger and softer, which is beneficial to the discharge of stool, and cellulose can also promote intestinal peristalsis, which accelerates defecation.

In addition, dietary fiber will be discharged with a small amount of cholesterol, fat and heavy metals in food, and you will feel light and relaxed.

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Prevention of colon cancer

Reason: The time of defecation is accelerated, which also means that it stays in the intestine for a shorter time, which can prevent carcinogens from contacting with the easily infected intestinal mucosa for a long time, thus reducing the possibility of canceration.

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The above six points are the efficacy of dietary fiber. See, it is simply a warm man who cares about everything and has a central air conditioning level!

In this era of obesity, diabetes and heart disease, dietary fiber is the hero to save mankind!

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Hurry up and pass it on to those people around you who don’t like fruits and vegetables, and let them see what a pity it is!

Since dietary fiber is so great, which foods have high dietary fiber content? Please accept this form.

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(Click to enlarge)

Here, dogs want to focus on the category of vegetables. Generally speaking, the dietary fiber content of wild vegetables is higher than that of cultivated vegetables, and dark green vegetables are higher than that of light-colored vegetables.

So, are all vegetables high in dietary fiber?

No, usually fruit vegetables, such as tomatoes (0.5%), cucumbers (0.5%) and wax gourd (0.7%) are relatively low. So, you should know which vegetable to choose for constipation!

After seeing the last row of nuts, friends who want to lose weight and want to eat nuts can choose almonds.

Dietary fiber has so many benefits, so is it better to eat more?

No, too much intake is not good for human body, because dietary fiber can be combined with iron, calcium, zinc, etc., thus affecting the absorption and utilization of these elements, which will lead to malnutrition in the long run.

The standard is to consume 30g every day. Take tremella with high content in mushroom as an example. Eating about 100g is equivalent to 30g of dietary fiber. However, dogs don’t advise you to eat a single food to meet your needs, but to diversify your food. Unfortunately, according to statistics, the dietary fiber intake of Chinese residents is far from the standard.

Come on! You, with your plain appearance and average qualifications, finally have a chance to get ahead!

I hope that in the future dinner, everyone will stop vomiting-inducing toasts, but

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In order to help people make better use of it, the dog lists the questions that people often ask me and answers them uniformly.

1. Is the dietary fiber content of vegetables with tendons higher than that of vegetables without tendons?

NO! This truth is like a real rich man. You may not see that TA is wearing any famous brand from head to toe, but you really just can’t see it. For example, sweet potato does not contain gluten, but its cellulose content is much higher than that of Chinese cabbage with gluten. In addition, as we mentioned just now, there is no gluten in fungus, tremella and laver, but the dietary fiber content is very high.

2. Does chopping and breaking vegetables lose the healthy function of fiber?

Not really. Fiber can not be digested by human small intestine, so it can play a healthy role and will not be changed by physical treatment. Whether it is chopped or boiled, it will not change.

Yes, it is not afraid of chopping!

Studies have measured the swelling power and water-holding capacity of dietary fiber from burdock residue, and the swelling power and water-holding capacity of dietary fiber are basically unchanged when it is crushed in the range of 355um-250um. However, under normal circumstances, we don’t need to break it too much, because other oxidizable nutrients will be lost, and secondly, we will eat more food.

3. Does the more dietary fiber you eat, the more you lose weight?

Dietary fiber absorbs water and expands in the stomach, resulting in satiety, reducing eating other foods and really helping to lose weight. However, if you eat dietary fiber without reducing the intake of other foods, it will not help you lose weight.

At present, there are many biscuits with high dietary fiber on the market, saying that they can lose weight. The dog wants to explain that you may get fatter and fatter as you eat them. Because dietary fiber can’t be digested, especially insoluble dietary fiber, the taste is not good. In order to avoid stinging, a lot of oil will be added to improve the taste. You may eat more fat than dietary fiber, so don’t be superstitious.

That’s all for today’s cold knowledge. I believe you will work hard to reach the standard and win at a healthy starting line. After all, something good will happen to those who live long enough.

Summary: the role of dietary fiber

1. Weight control is beneficial to lose weight.

2. Reduce serum cholesterol and prevent heart disease.

3. It is beneficial to control blood sugar and maintain balance.

4. Conducive to the growth of intestinal probiotics

5. Enhance intestinal function, which is beneficial to waste discharge.

Step 6 Prevent colon cancer

References:

[1] Sun Changyao, editor-in-chief. Nutrition and Food Hygiene. Eighth edition, People’s Health Publishing House, 2017.

[2] Yang Yuexin, Zhang Lishi, Mi Mantian. Public nutritionist. Beijing: China Labor and Social Security Press, 2012.

Yang Yuexin, Wang Guangya, Pan Xingchang. China Food Composition Table. Beijing: Peking University Medical Press, 2002.

[4] Fan Zhihong, N rumors about dietary fiber, 2009.

Xu Jing, Zhang Tao, Jiang Bo, et al. Study on the structure and physical properties of dietary fiber particles from burdock residue [J]. Food Industry Science and Technology, 2010,7:026.

Editorial Department of China Clinical Nutrition Network

Dynamic column of this site:

Original title: "[Popular Science Nutrition] Is eating dietary fiber just to lose weight? You underestimate its power! 》

Read the original text

News BBC released the list of the top 100 dramas in the 21st century.

The top ten on the list are FireWire, Mad Men, Breaking Bad, Life in London, Game of Thrones, I can destroy you, Watch the Earth, American spy dreams, Laughing at the Office, and The Battle of Inheritance.　

A Lang, editor-in-chief of our magazine, was also invited to submit a list of his top ten plays, including Life in London, Battle of Inheritance and Game of Thrones.

# Movie News #

?　Riz Ahmed’s Talk on [Venom: Deadly Guardian] and Actor’s Self-cognition.

"I’m not saying that I don’t like these blockbusters, I just don’t know how to put myself in.

Those movies can teach you endurance, technology and craft, and can dig out your own artistry in that environment, which is also a skill.

Look at javier bardem in [007: Breaking the Sky]. At that time, I had not developed this set of skills to support my technical and emotional expression. "

"The idea of creating masks and wearing masks is very natural to me, because I am a person who grew up alternately between different cultural environments and class environments.

Performance is actually through’ transformation’(change yourself)To adapt to different environments, and recently I’m thinking about taking off my mask.

Of course, if you feel deep down that you are not who you really are-the right skin color, appearance, accent, etc.-then you will instinctively wear a mask.

So for me, this is a change of self-awareness, and I will say,’ You know what? I am perfect, we are all perfect.’ "

[memento mori],Nolan, don’t use Pete, use the new guy.

When casting [Amnesia Fragments], Brad Pitt was once considered as one of the most suitable candidates in the industry, but Christopher Nolan hoped to play it with a new person.

Guy pearce took the initiative to call Nolan after learning about it. He also knew that it sounded awkward for the actor to ask the director for the role, but he just felt that the role was very suitable for him.

Fortunately, Nolan feels the same way.

? Review the 1984 edition [Dune]

The new version of Dune will be released soon, and those who haven’t seen the 1984 version should hurry up.

Many Hollywood blockbusters that fail in business are often full of glamour:

The suspension change of the project, the legendary director’s tired memories, the adaptation of the original work, and the wonderful difference between the film itself and the current interest, from [sand dune] to [sand dune], can be much more than from worm to worm.

These are all reasons for aftertaste.

Emily Blunt joins Nolan’s new film.

Emily Blunt confirmed to join Nolan’s new World War II film [Oppenheimer]!

The film revolves around the story of Robert Oppenheimer, the father of the atomic bomb, and is expected to be released on July 21st, 2023.

This is also the collaboration between Emily and Cillian Murphy, the leading actor of this film, after Silent Land 2.

?　[Eternal Family] Many starring COVID-19 are closely connected.

Actors Angelina Jolie, salma hayek, gemma chan and Lauren Liedloff, who were scheduled to attend ELLE’s Hollywood Women’s Dinner, were cancelled before the event, because they had "had contact with people diagnosed in COVID-19".

And four actors have also appeared at the world premiere of the movie [Eternal Family] before. In this regard, a Disney official said:

[Eternal Family] The next publicity activities will be held online instead of offline. Up to now, COVID-19, the leading actor of [Eternal Family], has tested negative.

? Asghar farhadi’s new work [A Hero] officially confirmed his bid for the 94th Oscar for Best International Film.

The film tells that Rahim was imprisoned because he was unable to repay his debts. During his two-day parole, he tried to persuade his creditors to withdraw their complaints about paying part of the money, but things did not go as planned. ……

This film won the jury prize of the main competition unit of the 74th Cannes Film Festival.

Fahati will attack his third Oscar statuette after [a separation] and [a salesman].

? Amazon takes Garth Davis.([Lion])Global distribution rights of the new sci-fi thriller [enemy]

Starring Saoirse Ronan, Paul Meska and Aaron Pierre, the film tells the story of a husband who was selected to enter a large experimental space station, and their lives fell into chaos.

It is said that the transaction amount is as high as $30 million.

? A preview of kenneth branagh’s new film [Belfast]

The film, starring caitriona balfe, Judi Dench and jamie dornan, is set in the late 1960s and revolves around the life of a boy in a turbulent period.

The film will be released in North America on November 12th.

? Restricted explosions of Chinese movies

Recently, Netflix’s hit Korean drama "Squid Game" has caused concern and discussion about "teenagers imitating violent games in the drama" in many areas.

On the other hand, in China, in fact, there have been many big Chinese movies that were classified as restricted when they were released abroad.

Among the top ten films in China’s film history, six films were rated as restricted in different countries or regions:

[Wolf Warriors 2]In Alberta, Canada, it is rated as 18A (viewers under 18 must be accompanied by adults).

[Wandering Earth]It is rated as Grade 15 in Britain (suitable for viewers over 15).

[detective chinatown 3]In the United States, it is rated as R (restricted, recommended for viewers over 17 years old).

[Operation Red Sea]It is rated as 18A in many places in Canada (viewers under 18 must be accompanied by adults).

[Chinatown Detective Case 2]In the United States, it is rated as R (restricted, recommended for viewers over 17 years old).

[Mermaid]In the United States, it is rated as R (restricted, recommended for viewers over 17 years old).

The Survival Crisis of Disney in Early Years

Today, Disney is the entertainment overlord, but in the 1940s, it encountered a crisis of survival earlier than other Hollywood giants.

Pinocchio (1940) and Fantasia (1940) failed to continue the commercial success of Snow White, which led to the double financial pressure of Disney.

Within the company, too strict hierarchy led to a large number of animators going on strike and joining competitors, such as MGM or Warner’s animation department.

Then, the United States was involved in World War II, and a large number of animators became government employees to create propaganda animations, which led to the shelving and delay of projects such as Peter Pan, Alice in Wonderland and Beauty and the Tramp.

For the sake of the company’s survival,"suit animation"(The Package Films) has become an emergency measure of the studio, and has produced a loose mode of South American family, music mix and match, short film duet and so on.

The representatives of the first category, namely [To My Friends ](1942) and [Three Horsemen ](1944), are stories with political propaganda.

The second category is [Music for Me ](1946), [Melody Time ](1948) and other short stories that mix and match various musical forms;

The last category is similar to [The Great Adventure of Teacher Yi and Little Toad ](1949). The short stories in it could have been longer and more complete works, but they could not be continued because of the constraints, or they were greatly simplified and had to be packaged and produced.

These animations honed the animators of the studio at that time, and also earned Disney money to tide over the crisis.

?　Ryuhei Matsuda gets married.

Actor Ryuhei Matsuda ([The Story of a Boat]) and British-Japanese mixed-race model Morgan Moyaro announced their marriage, and they have been dating for two years. Morgan is pregnant at present, and the due date is next spring.

Next year, we will focus on smart driving. Will BYD start the battle of ＂smart driving and equal rights＂？

In addition to new energy popularization, BYD may soon usher in a new label: smart driving popularization.

Recently, the Ministry of Industry and Information Technology announced the last new car declaration catalogue this year, and BYD’s new cars are listed. In addition to the brand-new models such as Equation Leopard Titanium 3 and UAV version, many new models including new models, new models, Sea Lion 05, Sea Lion 07, and new Qin PLUS have attracted wide attention in the market.

Judging from the application information of various new cars, BYD brand new cars such as the new Seagull, the new Dolphin and the new Qin PLUS will all provide "optional interior rearview mirror mounting base". This configuration actually means that these models will be equipped with a "three-eye visual hardware intelligent driving scheme", which can realize pure visual intelligent driving through multiple cameras in the whole car.

We also learned from relevant channels that the smart driving versions of new models, including 05, Dolphin and Sea Lion 07, are expected to be put on the market one after another in the first quarter of next year. According to the arrangement of Jielan Road, in addition to the series of products such as seagulls, dolphins, seals and sea lions modified by Ocean Net, Qin PLUS, Qin Plus and Han and Tang Family of Wang Chaowang will also be equipped with a three-eye visual hardware solution.

This means that after experiencing the strategy of "the same price of oil and electricity" and "electricity is lower than oil", the direction of the change of BYD brand hot models next year will mainly focus on smart driving. Starting from the first quarter of next year, BYD may change its lineup to promote the popularity of smart driving in the mainstream consumer market.

Previously, Zhang Zhuo, general manager of BYD Ocean Network, once said in an interview with the media that he hoped that BYD’s self-produced and self-sold intelligent driving system would be fully realized as standard in the models of about 150,000 yuan or even less in 2-3 years. Now it seems that 2025 is likely to be a crucial year for the large-scale popularization of BYD’s smart driving.

As BYD’s pure vision intelligent driving route scheme, the three-eye hardware vision scheme, as its name implies, covers different scenes through three cameras. Compared with monocular and binocular camera schemes, the three-eye hardware scheme has a wider field of vision and higher recognition accuracy.

Most importantly, compared with the lidar scheme, the hardware cost of the pure vision scheme independent of lidar will be lower. Cost is often the most important premise before the popularization and promotion of science and technology.

In order to reduce costs and improve their comprehensive competitive advantages, the second brand Ledao, including Xpeng Motors and Weilai Automobile, has adopted the pure vision intelligent driving scheme. Among them, Tucki P7+ is the first vehicle in Xpeng Motors to adopt the AI Hawkeye vision scheme, and Tucki P7+ AI intelligent driving can be independent of high-precision maps and lidar, and can adapt to the whole vehicle system with a set of software.

According to the latest data, the delivery volume of Tucki P7+ has exceeded 10,000 units only four weeks after listing, and the production has been expanded three times in one month. Through Tucki P7+, Xpeng Motors has obviously fired the first shot of the pure vision scheme.

According to Xpeng Motors, Tucki P7+ and subsequent models will no longer distinguish Max and Pro versions, and all models will be equipped with AI intelligent driving as standard. In addition to Tucki, the second-generation AION V and AION RT, which were launched by Guangzhou Automobile Ai ‘an before, all supported high-speed and map-free city navigation assistance. Although the intelligent driving scheme was not purely visual, it was realized by laser radar, but the prices of the second-generation AION V and AION RT also reached the mainstream price range of 150,000.

There are many other examples like this. For example, those equipped with Huawei’s Gankun Intelligent Driving ADS SE version have also reached the level of 150,000. The Baas version starts at a price of 149,900 yuan, and comes standard with 30 sensing hardware, which can realize high-speed NOA and full-scene navigation assistance NOA. In order to improve the competitiveness of new cars, the official has also given the free use right of full-scene navigation assistance NOA for five years.

The most noteworthy thing is Tesla. At the Tesla conference in October this year, Tess’s driverless taxi can achieve full automatic driving. According to Musk, the cost of Cybercab vehicles will be less than $30,000. Although the large-scale commercial production of this technology still needs a certain period, it has also caused expectations and optimism for Tesla to promote self-driving models into the mainstream market.

It can be seen that both lidar and pure vision scheme are just a means. From the ultimate goal, promoting the popularization and equal rights of high-level intelligent driving experience and occupying the mainstream market has increasingly become the consensus of all head car companies around the next stage of intelligent driving competition.

In this context, as a cliff-leading existence in the new energy market, BYD obviously needs to fill its shortcomings and improve its high-level intellectual driving competitiveness, so as to ensure its influence in the mainstream consumer market.

Since the beginning of this year, BYD has diversified its layout around the field of smart driving. For example, Equation Leopard has signed an in-depth strategic cooperation agreement with Huawei, and the first hard-core off-road SUV Equation Leopard equipped with Huawei’s Gankun Intelligent Driving ADS3.0 Intelligent Driving Scheme has come into the market, which can realize the whole scene from "parking space to parking space".

Besides the strategic cooperation with Huawei, before this year, BYD also had strategic cooperation with suppliers such as Horizon, Momenta, Baidu, NVIDIA and Bosch.

At the product level, since the beginning of this year, some mid-to-high-end and high-end models have also been equipped with BYD’s self-developed "Eye of God" intelligent driving scheme. Around self-research, BYD has set up two intelligent driving teams, Tianxuan and Sirius, in the middle of this year. The former is responsible for the high-order scheme, and the latter is oriented to the middle and low-order scheme.

In order to improve the efficiency of research and development, in October, the two teams completed the integration. This action of resource integration is also regarded by the outside world as a signal of BYD’s sprint and self-developed mass production. Although BYD’s smart driving performance is not excellent at this stage, it is believed that BYD will build a new moat in the new energy market on the basis of the bargaining power of supply chain brought by scale and the huge reputation of new energy in the first half, with BYD constantly strengthening its smart driving ability.

International observation： Russian economy meets challenges in recovery

    Xinhua News Agency, Moscow, January 7th　Title: Russian economy meets challenges in recovery.

    Xinhua News Agency reporter Huang He

    Although the impact of the Ukrainian crisis and western sanctions on Russia continues, the Russian economy as a whole showed a recovery momentum in 2023, and the economic growth rate exceeded the expectations of the Russian government and many international institutions. But at the same time, the Russian economy has also exposed some problems and challenges. Analysts predict that the Russian government may take measures this year to promote balanced industrial development, improve production efficiency, and implement a relatively tight monetary policy to curb inflation and promote sustained economic growth.

　　This is the Kremlin (left) and St. Vassili’s church after the snow in Moscow, Russia, on January 6. (Xinhua News Agency reporter Cao Yangshe)

   Triple factors help economic recovery

    In 2023, the Russian economy showed a recovery momentum. Russian President Vladimir Putin recently summed up the situation of Russia’s economic development in 2023 in the face of the "annual inventory" activities of the media and the public, saying that compared with the 2.1% contraction of gross domestic product (GDP) in 2022, Russia’s GDP is expected to increase by 3.5% in 2023.

    Putin said that in 2023, Russian industrial production is expected to increase by 3.6%, manufacturing industry by 7.5% and investment in fixed assets by 10%. At the same time, the profits of Russian enterprises are expected to increase by 24%, and the wage income of residents is expected to increase by 8%.

    Nikyshina, general manager of the Russian Export Center, told Xinhua that Russia has successfully overcome the pressure of sanctions imposed by the West since last year, and the goal of "the West hopes to crush Russia’s economy and crowd Russia out of the international trade chain through sanctions" has not been realized. "Russia has not been isolated from international trade, but is a very active participant in the world market."

　　On January 6, in Moscow, the Russian capital, the staff drove a snow removal vehicle to clear the snow on the road. (Xinhua News Agency reporter Cao Yangshe)

    Analysts believe that Russia’s economic growth last year benefited from three aspects. First of all, the relatively stable export income of energy and grain, and the improvement of manufacturing and consumption have provided support for economic growth. The relatively stable export income of energy and grain is an important factor to promote Russian economic growth. At the same time, Russian official data show that about one-third of Russia’s economic growth in 2023 comes from the military-industrial complex and related electronics, computers, optics and other industries.

    Second, financial control measures have been effective. Since last summer, the ruble has been depreciating, and the exchange rate of the US dollar against the ruble has repeatedly exceeded 1 to 100. In this regard, Russia has introduced strict control measures, requiring some export enterprises to carry forward foreign exchange income in the domestic market, and strengthening financial supervision of related enterprises to reduce the volatility of the ruble by regulating foreign exchange liquidity.

    Moreover, Russia has broken through the western blockade in international trade. Since 2023, on the one hand, Russia has vigorously developed trade with "friendly countries", on the other hand, it has actively promoted the use of local currency in international settlement. Russian Prime Minister Dmitry Mishustin said that the trade volume between Russia and "friendly countries" is increasing rapidly in Russia’s total foreign trade. In addition, by the end of 2023, the share of local currency settlement between Russia and other countries is expected to reach 65%.

　　On January 1, people took the subway New Year train in Moscow, Russia. (Photo by Xinhua News Agency reporter Bai Xueyu)

   Multiple challenges constrain sustained growth

    Russia still faces many risks and challenges to achieve sustained growth. Analysts pointed out that in addition to external sanctions, the Russian economy also faces challenges such as industrial imbalance, inflationary pressure and labor shortage.

    On the one hand, the growth model driven by military production may be difficult to sustain. Last year, the Russian military’s industrial production increased substantially, but the production of civilian products requiring complex technological processing capacity decreased significantly. Analysts believe that the current economic growth model that relies too much on military production is not only unsustainable, but may even further push up inflation.

    On the other hand, the pressure of stabilizing prices, ensuring supply and reducing inflation continues to increase. According to the reporter’s observation, in big cities such as Moscow and St. Petersburg, the supply of fruits, vegetables and meat is still tight or the prices have risen sharply. In order to curb inflation, the Russian central bank recently raised the benchmark interest rate to 16%. Nabiulina, governor of the Russian central bank, said that the fundamental reason for the high inflation is that the current production cannot immediately meet the growing demand.

    Moreover, the shortage of labor will also restrict the sustainable economic growth. At present, the unemployment rate in Russia is at an all-time low of 2.9%. According to "Russian newspaper", the current employment gap in Russian manufacturing industry is 660,000, and the employment gap in agriculture is 200,000. Berenikaya, a macroeconomic analyst at the Russian investment company, said that the labor shortage is related to Russia’s long-standing population problem, as well as the impact of special military operations and national defense production on the labor market.

　　On December 21, 2023, in Moscow, the Russian capital, people hugged under the New Year fir tree. Xinhua News Agency (photo by Alexander)

   Multiple measures to stabilize economic operation

    Considering that many unfavorable factors may inhibit the economic growth momentum, Russia’s economic growth rate may slow down this year. The Russian central bank predicts that the Russian economic growth rate will be between 0.5% and 1.5% in 2024.

    Analysts predict that the focus of the Russian government’s economic policy in 2024 will be to promote balanced industrial development, improve production efficiency, and at the same time cooperate with relatively tight monetary policy to curb inflation. In order to promote economic growth, in 2024, the Russian government is expected to increase efforts to support enterprises to invest in production, develop new technologies and strengthen personnel training.

    Maxim Oreshkin, adviser to the Russian President, said that improving the level of production automation is one of the top priorities of the Russian government in the future, and "high-quality talents and automation are two key factors that determine the long-term development level of the Russian economy".

    The Russian central bank recently predicted that by the end of 2023, Russia’s inflation level will be between 7% and 7.5%, far exceeding the target level of 4%. The Russian government hopes that the inflation rate will fall back to 4% to 4.5% by the end of 2024. Nabiulina said, "This means that we will maintain a tight monetary policy for a long time to come."

HarmonyOS Zhixing S800 luxury car was unveiled, and Huawei Mate 70 series was released on the same stage.

On November 22nd, HarmonyOS Zhixing announced that its Zunjie brand’s first luxury car "Zunjie S800" will be unveiled at the Huawei Mate 70 series mobile phone conference on November 26th. Zunjie S800 is highly anticipated for its unique design and luxurious configuration. It is reported that the size of the model is about 5.5 meters, the interior space is spacious, and the body color is purple and silver. The front of the car is designed with vertical and horizontal star Han and Xinghe headlights, and the door handle of the car is bright with Xinghe scroll and rose nebula as design elements.

The design details of Zunjie S800 are full of futuristic and technological sense, such as the integration of crystal car light and car body, the luminous crystal section of logo, and the pie wheel hub. These designs not only improve the aesthetics of vehicles, but also reflect the innovation and breakthrough of HarmonyOS Zhixing in the field of smart cars. With the approaching of Huawei Mate 70 series mobile phone conference, more information of Zunjie S800 will be revealed, and the market is full of expectations for its performance.

One article to understand – Jaguar XEL can drive home 299,800

In the development of science and technology, the automotive industry has always been at the forefront, and advanced technology will be the first to arm the car. Such equipment is still very popular with consumers. Today, I picked a car among the medium-sized cars to introduce to you. It is. So whether this car is a mule or a horse, let’s take a look at its actual performance.

Take a look at the appearance of the Jaguar XEL first. The front face of the Jaguar XEL looks very domineering, with a black mesh grille, it looks relatively simple. Then with the headlights, it has a great visual impact. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing, etc. Come to the side of the car, the body size of the car is 4778MM*1850MM*1429MM, the car adopts a delicate line, the side circumference presents a domineering and stylish design style, with large-sized thick-walled tires, the overall visual effect is very simple. Looking back, the rear of the car looks very simple, the taillights look very young personality, coupled with the unique shape of the exhaust pipe, the overall look is very sturdy.

In terms of interior, the front face of the Jaguar XEL looks very stylish and simple, and the visual effect is very good. The appearance of the steering wheel of the car looks very good, equipped with functions such as manual up and down + front and rear adjustment of the steering wheel, giving people a bright feeling. Take a look at the central control, with a 10.25-inch touch LCD central control screen, which makes the interior design quite layered and looks quite dynamic. Let’s take a look at the dashboard and seats. The car is equipped with a streamlined dashboard, and the trendy design elements make people remember it at a glance. The car uses imitation leather seats, which are well-wrapped and well-made. The materials are exquisite, and the ride is comfortable.

The Jaguar XEL is matched with a manual integrated (AT) gearbox, with a 100-kilometer acceleration time of 7.3s. The power performance is good, and it meets the needs of daily use.

The Jaguar XEL has no problem with two luggage bags in the trunk, and the rear seats cannot be reclined, which is a pity. In addition, the car is equipped with fatigue reminders, anti-lock brakes (ABS), LED daytime running lights, brake assistance (EBA/BAS, etc.), braking force distribution (EBD) main driver airbags, passenger seat airbags, side air curtains, front side airbags, and other safety features.

After reading this car, I believe you have a general understanding. This car performs well in terms of space and configuration. As for the exterior design, everyone has their own unique aesthetic.

Honda CR-V price reduction news in Guangzhou, the latest offer 149,900! Discounts wait for no one

In the Autohome Guangzhou promotion channel, promotions are going on, bringing great value car buying opportunities to Guangzhou citizens. Now, the starting price of this high-profile SUV model is only 149,900 yuan, and the maximum discount amount is as high as 36,000 yuan. If you are looking for a compact SUV that is practical, durable and cost-effective, then the Honda CR-V is definitely worth your attention. Please click "Chatty Car Price" in the quotation form to get higher discounts and add more benefits to your car buying journey!

本田CR-V头图

Honda CR-V is a very popular compact SUV, and its exterior design is very delicate. The front face design of this car series adopts the design language of Honda family style, which has a very unique aesthetic feeling. The air intake grille is decorated with large-size chrome trim, which looks very atmospheric. In terms of overall style, CR-V’s design is very smooth, with simple lines and coordinated body proportions, creating a very fashionable feeling. In addition, CR-V also adopts LED headlights and fog lights, which not only improve the lighting effect, but also make the whole body more delicate. Overall, CR-V’s exterior design is excellent, and it is a very attractive model.

本田CR-V正侧

Honda CR-V is a medium-sized SUV. Its body size is 4703 * 1866 * 1680mm, the wheelbase is 2701mm, the front wheelbase is 1611mm, and the rear wheelbase is 1627mm. The body has smooth lines, and the overall shape is fashionable and atmospheric. The side lines are simple and smooth, the roof lines are straight, and the window lines are smooth. The vehicle is equipped with 235/65 R17 specification front and rear tires. The wheel rim adopts a five-spoke design, and the shape is fashionable and dynamic. The exterior design of the vehicle is fashionable and atmospheric. The lines are smooth and full of power, which is very suitable for city life and family use.

本田CR-V中控全图

The interior design of the Honda CR-V is simple and generous, using a black and beige color scheme, and the overall atmosphere is relatively warm. The steering wheel is made of genuine leather, which feels comfortable, and the position can be manually adjusted up and down and back and forth. The central control screen size is 10.1 inches, and it supports automatic speech recognition control system, including multimedia system, navigation, telephone, air conditioning and car windows. Both the front and rear rows are equipped with USB and Type-C ports for easy charging. In addition, the front row also supports wireless charging function of mobile phones. The seats are made of genuine leather. The main driver seat can be adjusted back and forth, backrest adjustment, high and low adjustment and waist support. The passenger seat can also be adjusted back and forth and backrest adjustment. The second row of seats supports front and rear adjustment and backrest adjustment, and the rear seats can be proportionally reclined to provide more storage space. Overall, the interior design of the Honda CR-V focuses on practicality and comfort, and the configuration is also more abundant. It is a good family SUV model.

本田CR-V发动机舱

The Honda CR-V is equipped with a 1.5T 193 horsepower L4 engine with a maximum power of 142kW and a maximum torque of 243N · m. The model is equipped with a CVT continuously variable transmission, which can provide the driver with a smooth gear shifting experience. This engine not only has excellent acceleration performance, but also maintains a stable power output at high speeds, providing the driver with a comfortable and safe driving experience. At the same time, the engine also has high fuel economy, which can save the owner a lot of fuel bills. Overall, the Honda CR-V engine performs well and is a reliable car choice.

In the word-of-mouth of Autohome owners @that moment, he is full of praise for the appearance of the Honda CR-V. He mentioned that the CR-V is quite beautiful, and even made him give up the domineering appearance of the Camry. He is very satisfied with the appearance of the CR-V, especially the design and texture of the lights, which makes him the prettiest boy on the street at night. The CR-V has a length of about 4.7 meters, and the overall appearance is very large. The tail design is relatively mediocre. However, this did not affect his praise for the CR-V. Overall, the Honda CR-V is excellent in appearance design, especially in terms of appearance. The words of the Autohome owner @at that moment also made us deeply aware of the charm of this car.